Avocado/Soybean Unsaponifiables (ASU) Plus

$25.00$150.00

Typically, you will usually find ASU in capsule form. We have enhanced the product by first offering it as a freeze dried powder. Because it’s now a powder, we can almost double the typical amount of ASU (now 860 mg)/dosage. We are also using our Tart Cherry Powder (6 times more anthocyanins  than a USA grown tart cherry) as a carrier (6140 mg)/dosage. Lastly, we have added  (1000 mg)/dosage of Bacilus coagulans -2 billion cfu to enhance the bio-availability (absorption) of our  ASU Plus.
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Description

 

Management of Osteoarthritis with Avocado/Soybean Unsaponifiables

Blaine A. ChristiansenSimrit BhattiRamin Goudarzi, …   Cartilage. 2015 Jan; 6(1): 30–44.

Abstract

Osteoarthritis (OA) is a painful and life-altering disease that severely limits the daily activities of millions of Americans, and it is one of the most common causes of disability in the world. With obesity on the rise and the world’s population living longer, the prevalence of OA is expected to increase dramatically in the coming decades, generating burdensome socioeconomic costs. This review summarizes current pharmaceutical, non pharmaceutical, and prospective new treatments for OA, with primary focus on the dietary supplement avocado/soybean unsaponifiables (ASU). ASU modulates OA pathogenesis by inhibiting a number of molecules and pathways implicated in OA. Anticatabolic properties prevent cartilage degradation by inhibiting the release and activity of matrix metalloproteinases and increasing tissue inhibitors of these catabolic enzymes. ASU also inhibits fibrinolysis by stimulating the expression of plasminogen activator inhibitor. Anabolic properties promote cartilage repair by stimulating collagen and aggrecan synthesis via inhibition of inflammatory cytokines such as interleukin (IL)-1, IL-6, IL-8, tumor necrosis factor, ERK, and prostaglandin E2. Chondroprotective effects are mediated by correcting growth factor abnormalities, increasing TGF-β, and decreasing vascular endothelial growth factor (VEGF) in synovial fluid. ASU also inhibits cholesterol absorption and endogenous cholesterol biosynthesis, which mediate reactive oxygen species pathology in chondrocytes. At the clinical level, ASU reduces pain and stiffness while improving joint function, resulting in decreased dependence on analgesics.

References:

(1) Appelboom T, Schuermans J, Verbruggen G, Henrotin Y, Reginster JY. Symptoms modifying effect of avocado/soybean unsaponifiables (ASU) in knee osteoarthritis. A double blind, prospective, placebo-controlled study. Scand J Rheumatol 2001;30(4):242-247.

(2) Blotman F, Maheu E, Wulwik A, Caspard H, Lopez A. Efficacy and safety of avocado/soybean unsaponifiables in the treatment of symptomatic osteoarthritis of the knee and hip. A prospective, multicenter, three-month, randomized, double-blind, placebo-controlled trial. Rev Rhum Engl Ed 1997 Dec;64(12):825-834.

(3) Lequesne M, Maheu E, Cadet C, Dreiser RL. Structural effect of avocado/soybean unsaponifiables on joint space loss in osteoarthritis of the hip. Arthritis Rheum 2002 Feb;47(1):50-58.

(4) Maheu E, Mazieres B, Valat JP, Loyau G, Le Loet X, Bourgeois P, et al. Symptomatic efficacy of avocado/soybean unsaponifiables in the treatment of osteoarthritis of the knee and hip: a prospective, randomized, double-blind, placebo-controlled, multicenter clinical trial with a six-month treatment period and a two-month followup demonstrating a persistent effect. Arthritis Rheum 1998 Jan;41(1):81-91.

Avocado-soybean extract

Avocado and soybean oils are used for manufacturing soap and the unsaponifiables fraction from these oils is termed avocado/soybean unsaponifiables (ASU). ASU has been tested in the management of OA. ASU contains phytosterols, β-sitosterol, campesterol, and stigmasterol, fat soluble vitamins, triterpene fatty acids and possibly furan fatty acids, but the identity of the active components in it is unknown [1]. Several formulations of ASU are available on the market as supplements. Piascledine, which contains the unsaponifiables as one part from avocado and two from soybean, is a unique patented preparation [2]. In articular chondrocyte cultures ASU may modulate NFκβ levels to inhibit inflammatory cytokines and stimulate collagen synthesis [1]. Animal studies also support its benefits in OA.

A PubMed search in August 2015 with the words “avocado/ASU” and “osteoarthritis” and “knee” showed 25 entries of which five were human clinical trials on pain and function of OA in hip and knee (Table 1) . Literature on the human trials of ASU in hip and knee OA, and for the rationale of this therapy has been reviewed recently [1]. It is pointed out that there may be a conflict of interest in these studies. Also, one should consider that soybean protein alone may be beneficial for OA and this complicates the interpretation of the benefits of ASU [3].

The effect of ASU on patients with hip (n = 50) or knee (n = 114) OA was examined in a randomised, double blind, placebo controlled, multicenter trial with a 6 month treatment period (Table 1) [4]. After the 6 months its efficacy was greater than that of the placebo (P <0.001 for intergroup difference at month 6). The decrease in the Lequesne index (from 9.7 ± 0.3 to 6.8 ± 0.4) was significantly greater in the ASU group than in the placebo group (from 9.4 ± 0.3 to 8.9 ± 0.4). Fewer patients treated with ASU required NSAIDs (48 %) than those in the placebo group (63 %) (p = 0.054). The improvements appeared to be more marked in patients with hip than those with knee OA. Another similar study confirmed these findings [5]. In yet another study, the effects of two doses (300 or 600 mg daily) of ASU were compared in patients with knee OA over 3 months (Table 1) [6]. Both doses were effective. At day 90, NSAIDs and analgesics intake decreased to less than half in 71 % patients receiving ASU (300 mg or 600 mg) compared to 36 % in the placebo group (p <0.01). The Lequesne’s index dropped by 3.9, 2.9 and 1.9 points with 600 mg ASU, 300 mg ASU and placebo, respectively (p <0.01).

  1. Christiansen BA, Bhatti S, Goudarzi R, Emami S. Management of Osteoarthritis with Avocado/Soybean Unsaponifiables. Cartilage. 2015;6:30–44.
  2. Ragle RL, Sawitzke AD. Nutraceuticals in the management of osteoarthritis : a critical review. Drugs Aging. 2012;29:717–31.
  3. Arjmandi BH, Khalil DA, Lucas EA, Smith BJ, Sinichi N, Hodges SB, et al. Soy protein may alleviate osteoarthritis symptoms. Phytomedicine. 2004;11:567–75.
  4. Maheu E, Mazieres B, Valat JP, Loyau G, Le Loët X, Bourgeois P, et al. Symptomatic efficacy of avocado/soybean unsaponifiables in the treatment of osteoarthritis of the knee and hip: a prospective, randomized, double-blind, placebo-controlled, multicenter clinical trial with a six-month treatment period and a two-month followup demonstrating a persistent effect. Arthritis Rheum. 1998;41:81–91.
  5. Blotman F, Maheu E, Wulwik A, Caspard H, Lopez A. Efficacy and safety of avocado/soybean unsaponifiables in the treatment of symptomatic osteoarthritis of the knee and hip. A prospective, multicenter, three-month, randomized, double-blind, placebo-controlled trial. Rev Rhum Engl Ed. 1997;64:825–34.
  6. Appelboom T, Schuermans J, Verbruggen G, Henrotin Y, Reginster JY. Symptoms modifying effect of avocado/soybean unsaponifiables (ASU) in knee osteoarthritis. A double blind, prospective, placebo-controlled study. Scand J Rheumatol. 2001;30:242–7.

Additional information

Weight 1 lbs
Dimensions 2 × 2 × 4 in
Size

8 oz,, 5 lbs,, 44 lbs,

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