(Vegan, Non-GMO, Non-Allergen)
Melatonin is the principle hormone produced and secreted by the brain’s pineal gland and is responsible for maintaining circadian rhythm (the body’s biological clock)‚ regulating the endocrine (hormone) system and supporting the immune system. The level of melatonin produced by the body is heavily influenced by sunlight. At night‚ the secretion of melatonin is much higher than during the day. When this process is interrupted‚ certain symptoms can occur such as disruptions in the sleep/wake cycle‚ headaches‚ mental and physical fatigue and irritability.
Why is Melatonin important?
Low levels of melatonin could result in poor sleep patterns‚ low mood‚ delayed sleep phase syndrome‚ insomnia associated with attention deficit hyperactivity disorder‚ irritability‚ learning disorders‚ poor concentration‚ seasonal affective disorder‚ menstrual disturbances and headaches.
Melatonin plays an important role in when we fall asleep and when we wake up. Darkness stimulates the release of melatonin and light suppresses its activity. Normal melatonin cycles are disrupted when we are exposed to excessive light in the evening or too little light during the daytime. Melatonin supports sleep onset and quality of sleep and increased Rapid Eye Movement time‚ deep sleep and dreaming. These changes demonstrate better quality sleep‚ which produces greater mental‚ physical and emotional rejuvenation. Melatonin can decrease the amount of time required to fall asleep‚ increase the number of sleeping hours and support daytime alertness.
Jet Lag and Rotating Shift Work*
Jet lag and rotating shift work can interfere with the body’s natural circadian rhythm. Melatonin supports quality sleep and balanced circadian rhythms in people with disrupted circadian rhythms (such as those suffering from jet lag or poor vision or those who work the night shift) and those with low melatonin levels (such as some elderly).
Melatonin is also one of the hormones that controls the timing and release of female reproductive hormones. It helps determine when menstruation begins‚ the frequency and duration of menstrual cycles‚ and when menopause begins. It’s a powerful regulator of sex hormone production and can effect mood‚ immunity‚ reproduction and bone health. Melatonin supplements may benefit menopausal women by supporting and sustaining sleep and by supporting osteoblasts that support bone health.
Immune and Antioxidant Support*
Melatonin has strong antioxidant properties and helps support immune system strength. As an antioxidant it is 6 to 10 times more potent than vitamin E and is one of the few antioxidants that can enter the mitochondria to protect it from free radical damage.
Some people experience a depressed mood when the low sunlight levels (winter) are not sufficient for their pineal glands to decrease melatonin production to its normal low daytime level. Melatonin supplementation can support mood balance seasonally or in times of low mood. The consequences of sleep deprivation go far beyond fatigue and diminished performance. Sleep deprivation can impact the immune system, the nervous system, memory and cognitive impairment, mood, and more.1 Ultimately, lack of sleep leads to an overall poor quality of life. If you’re one of the more than 20 million Americans who suffer from occasional sleep problems,2 you don’t have to settle for frustrating nights of tossing and turning. A new, fast-acting liquid melatonin may enable you to take back control of your sleep.
Melatonin is well known for its ability to regulate your body’s internal clock. However, as you grow older, the secretion of melatonin declines significantly as the pineal gland becomes calcified.3,4 Fortunately, melatonin has been studied and shown to be effective for managing disturbances in circadian rhythms.5,6 A meta-analysis of 17 studies concluded that melatonin supplementation decreases the time it takes to fall asleep while increasing sleep efficiency and total sleep duration.7 In fact, melatonin has been shown to increase the speed of falling asleep—and the quality of sleep—in about 60% of people who use it.8,9
Decades of clinical research document that a good night’s rest supports nearly all systems of the body, including:
• Skin health and youthful appearance10,11
• Healthy collagen formation12
• Insulin levels already within normal range13,14
• Healthy body weight15,16
• Glucose levels already within normal range17,18
• Blood pressure already within normal range13,19
• Healthy cell division20
• Cardiovascular health21,22
• A good mood23
Liposomal Delivery System
A Liposomal liquid delivery system allows for flexible‚ convenient dosing of Melatonin in order to address individual requirements. Liposomal technology helps to maintain the health benefits of Melatonin by protecting it from the degradative environment of the stomach. This is especially beneficial for patients who have had gastric bypass or general gastro-intestinal dysfunction. Liposomal encapsulation of ingredients represents a new delivery system that appears to offer important advantages over existing methods of delivery.
1. Available at: http://www.webmd.com/sleep-disorders/features/important-sleep-habits
2. Available at: http://www.nlm.nih.gov/medlin¬eplus/tutorials/sleepdisorders/nr249104.pdf
3. Exp Gerontol. 2001 Jul;36(7):1083-100.
4. J Pineal Res. 1994 May;16(4):178-83.
5. Neuroimmunomodulation. 2006;13(3):133-44.
6. Travel Med Infect Dis. 2008 Jan;6(1-2):17-28.
7. Sleep Med Rev. 2005;9(1):41-50.
8. Clin Pharmacol Ther. 1995 May;57(5):552-8.
9. Actas Esp Psiquiatr. 2000 Sep-Oct;28(5):325-9.
10. J Invest Dermatol. 2001 Aug;117(2):309-17.
11. Bioengineering of the Skin: Skin Surface Imaging and Analysis. Boca Raton, FL: CRC Press LLC; 1997:337.
12. Med Hypotheses. 2010 Dec;75(6):535-7.
13. Obes Rev. 2009 Nov;10 Suppl 2:37-45.
14. Science. 2010 Dec 3;330(6009):1349-54.
15. J Clin Sleep Med. 2007 Dec 15;3(7):681-8.
16. Obesity (Silver Spring). 2009 Apr;17(4):767-71.
17. Horm Res. 2007;67 Suppl 1:2-9.
18. Ann N Y Acad Sci. 2008;1129:287-304.
19. Am J Hypertens. 2010 Dec;23(12):1286-91.
20. Chronobiol Int. 2011 Feb;28(1):76-80.
21. Prog Cardiovasc Dis. 2009 Jan-Feb;51(4):294-302.
22. Sleep. 2010 Aug 1;33(8):1037-42.
23. Psychiatry Clin Neurosci. 2003 Jun;57(3):265-70.
*These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.