(Vegan, Non-GMO, Non-Allergen)
• Boosts Energy Levels*
• Supports Healthy Weight Management*
• Enhances Carbohydrate/Fat Utilization & Metabolism*
• Natural Sleep Aid*
• Promotes Mental Clarity/Health, Memory & Brain Function*
• Natural Anti-Depressant*
• Promotes Healthy Digestive System & Function*
• Promotes Formation/Function of Healthy Red Blood Cells*
• Promotes Optimal Function of Central Nervous System*
• Potential Protection From Alzheimer’s and Atherosclerosis*
• Promotes Healthy Skin, Hair, and Nails*
“I believe vitamin B12 deficiency to be one of the most common nutrient deficiencies in the United States today because of inadequate vitamin B12 levels in food and a poor absorption of vitamin B12 associated with aging. It is impossible to have a properly functioning thyroid gland without adequate vitamin B12 levels in the body.” David Brownstein, Overcoming Thyroid Disorders
The Essential Vitamin For Almost ALL Life Functions
Pair’s Liposomal Vitamin B12 provides near 100% BioAvailability & Absorption compared to traditional tablet & pill form B12 supplements. Vitamin B12 is Known as the “Energy Vitamin” Vitamin B12 is crucial for nearly every metabolic process within the human body. IT’S BEEN CALLED NATURE’S MOST NEEDED VITAMIN!
Vitamin B12 is an essential water-soluble vitamin that is commonly found in a variety of foods, such as fish, shellfish, meat, eggs, and dairy products. Vitamin B12 plays an important role in supplying essential methyl groups for protein and DNA synthesis. Vitamin B12 is bound to the protein in food. Vitamin B12 helps maintain a healthy digestive system and protects against heart disease by curbing and improving unhealthy cholesterol levels, protecting against stroke, and fighting high blood pressure.
As we age, it is estimated that at least 50% of people will be unable to absorb the Vitamin B12 benefits found in foods, thus needing supplementation.
Vitamin B12 is needed to convert carbohydrates into glucose in the body, thus leading to energy production and a decrease in fatigue and lethargy in the body. Of all vitamins, Vitamin B12 is the most complex chemically and biologically. Without it, your body is incapable of functioning at its full potential. Vitamin B12 helps in healthy regulation of the nervous system, reducing depression, stress, and brain shrinkage. Vitamin B12 is also essential for healthy skin, hair, and nails. It helps in cell reproduction and constant renewal of the skin.
Vitamin B12 Published Medical Quotes
• A study reported in the American Journal of Obstetrics and Gynecology in 2004 found that women who gave birth to children with Spina Bifida had vitamin B12 levels that were 21 percent lower than those of mothers who had had healthy children. Vitamin B12 is also linked to the production of acetylcholine, a neurotransmitter that assists memory and learning. (1)
• Vitamin B12 supplementation has been shown to enhance sleep patterns, allowing for more restful and refreshing sleep. (2)
• A vitamin B12 deficiency can be caused by malabsorption, which is most common in older adults and in people with digestive disorders. (3)
• Many older people become deficient in vitamin B12 because they do not produce adequate amounts of stomach acid for proper digestion. This creates a perfect environment for the overgrowth of certain bacteria that steal whatever vitamin B12 is extracted from protein in the digestive tract. Other people do not produce enough of a substance called intrinsic factor, without which vitamin B12 cannot travel from the stomach to the rest of the body, even if nothing else is standing in its way. One can have vitality and a zest for living at any age. You should not assume that pain and illness are inevitable parts of aging. You can feel better at 60 than you did at 30 by making healthy changes in your diet and lifestyle. (4)
• “One study found that women over 64 with low levels of vitamin B12 were far more susceptible to osteoporotic bone loss. (5)
• Given the importance to the immune system of maintaining good nutritional status, low serum vitamin B12 levels may signify that overall nutritional status is quite poor — a harbinger of further impairment of immune status and progression to AIDS. A low level of vitamin B12 is associated with faster progression from HIV to AIDS. In addition, vitamin B12 has been shown to inhibit HIV replication in vitro. Given the safety of achieving high blood and tissue levels of vitamin B12 without toxicity, vitamin B12 therapy for HIV infection holds great promise. (6)
• As a result, signs and symptoms of vitamin B12 deficiency may not show themselves until after five to six years of poor dietary intake or inadequate secretion of intrinsic factor. Since normal body stores of vitamin B12 may last an individual three to six years, deficiency of vitamin B12 is usually not apparent in a vegetarian until after many years. The classic symptom of vitamin B12 deficiency is pernicious anemia. However, it appears that a deficiency of vitamin B12 will actually affect the brain and nervous system first. (7)
• “More specifically, vitamin B12 deficiency results in impaired nerve function, which can cause numbness, “pins and needles” sensations, or a burning feeling in the feet, as well as impaired mental function, which in the elderly can mimic Alzheimer’s disease. In addition to depression or mental confusion, vitamin B12 deficiency can present as anemia; a smooth, beefy red tongue; and diarrhea. Vitamin B12 deficiency is thought to be quite common in the elderly. (8)
• A deficiency of vitamin B12 results in significantly reduced white blood cell production and abnormal white blood cell responses. A B12 deficiency produces identical findings and is especially harmful to the ability of white blood cells to engulf and destroy infecting organisms. (9)
• In order for vitamin B12 to be absorbed, it must be liberated from food by hydrochloric acid and bond to a substance known as intrinsic factor within the small intestine. Lack of intrinsic factor results in a condition known as pernicious anemia. Pernicious anemia is frequently associated with iron deficiency as well. A dietary lack of vitamin B12 is most often associated with a strict vegetarian diet. (10)
• Although it is popular to inject vitamin B12 in the treatment of vitamin B12 deficiency, injection is not necessary as the oral administration of an appropriate dosage has been shown to produce excellent results. (11)
• Deficiencies of folic acid and vitamin B12 may cause some cases of recurrent canker sores, says Flora Parsa Stay, D.D.S., a dentist in Oxnard, California. If you have recurrent sores, she recommends taking vitamin B12 daily. (12)
• Anemia is a condition in which the blood is deficient in either red blood cells or hemoglobin, the ironbinding protein that transports oxygen through the blood. Red blood cells transport oxygen from the lungs to the tissues of the body, exchanging fresh oxygen for carbon dioxide, which is excreted by being exhaled. The symptoms of anemia result from a failure of the red blood cells to provide oxygen efficiently. These symptoms include pallor, breathlessness, weakness, a tendency to tire easily, loss of appetite, constipation, headaches, difficulty concentrating, and coldness of the hands and feet. (13)
• Pernicious anemia is a severe form of anemia that is due to vitamin B12 deficiency. Persons with this disorder cannot absorb any form of vitamin B12 from the gastrointestinal tract. Malabsorption can cause pernicious anemia, as can poor eating habits, gastrointestinal infection, Crohn’s disease, gastric surgery, and sometimes even strict vegetarianism. If B12 levels fall too far, the result is lagging energy, depression, indigestion, diarrhea, and anemia. Ongoing vitamin B12 deficiency carries a risk of neurological damage. The most common cause of anemia is iron deficiency. Iron is an important factor in anemia because this mineral is used to make hemoglobin, the component of red blood cells that attaches to oxygen and transports it. (14)
• Vitamin B12 deficiency often appears very gradually. Patients may describe complaints such as mental fuzziness, a sensation of burning on the tongue, or poor coordination for months or even years before a proper diagnosis is made. Anyone who has been on PPIs for many months (or years) should request a blood test for iron and vitamin B12. It’s not enough to just look for vitamin B12, though. Be sure to be tested for serum cobalamin (that is vitamin B12) and methylmalonic acid (MMA). When MMA is elevated and cobalamin is low, that is an indication of a probable vitamin B12 deficiency. (15)
• Vitamin B12 is made by microorganisms found in the soil and by microorganisms in the intestines of animals, including our own. The amount made in our intestines is not adequately absorbed, so it is recommended that we consume B12 in food. Research has convincingly shown that plants grown in healthy soil that has a good concentration of vitamin B12 will readily absorb this nutrient. However,plants grown in “lifeless” soil (non-organic soil) may be deficient in vitamin B12. In the United States, most of our agriculture takes place on relatively lifeless soil, decimated from years of unnatural pesticide, herbicide and fertilizer use. (16)
• Another medicine that helps some patients feel better is vitamin B12. One study done many years ago did suggest that it could improve general wellbeing, but with only limited effects on fatigue. Medical students are taught that vitamins are useful only in patients who, for one reason or another, have a vitamin deficiency. However, enough patients have reported that vitamin B12 is helpful that I am willing to try this, especially because this vitamin is not toxic and costs so little. (17)
• I believe vitamin B12 deficiency to be one of the most common nutrient deficiencies in the United States today because of inadequate vitamin B12 levels in food and a poor absorption of vitamin B12 associated with aging. It is impossible to have a properly functioning thyroid gland without adequate vitamin B12 levels in the body. (18)
(1-5) Phyllis A. Balch, CNC, Prescription for Nutritional Healing, 4th Edition: A Practical A-to-Z Reference to Drug-Free Remedies Using Vitamins, Minerals, Herbs & Food Supplement
(6-11) Michael T. Murray, N.D., Joseph E. Pizzorno, N.D., Encyclopedia of Natural Medicine, Revised Second Edition
(12) Bill Gottlieb, Alternative Cures: The Most Effective Natural Home Remedies for 160 Health Problems
(13-14) Phyllis A. Balch, CNC, Prescription for Herbal Healing: An Easy-to-Use A-Z Reference to Hundreds of Common Disorders and Their Herbal Remedies
(15) Joe Graedon, M.S. and Teresa Graedon, Ph.D., Best Choices From the People’s Pharmacy
(16) T. Colin Campbell, Ph.D. and Thomas M. Campbell II, The China Study: The Most Comprehensive Study of Nutrition Ever Conducted and the Startling Implications for Diet, Weight Loss and Long-term Health
(17) Benjamin H. Natelson, M.D., Your Symptoms Are Real: What to Do When Your Doctor Says Nothing Is Wrong
(18) David Brownstein, Overcoming Thyroid Disorders
Vitamin B12 Clinical Research
• B vitamins appear to slow cognitive and clinical decline in people with MCI, in particular in those with elevated homocysteine. (1)
• The accelerated rate of brain atrophy in elderly with mild cognitive impairment can be slowed by treatment with homocysteine-lowering B vitamins. (2)
• Vitamin B12 deficiency should always be looked for in MS. The deficiency may aggravate MS or impair recovery. There is evidence that vitamin B12 is important for myelin synthesis and integrity but further basic studies are required. (3)
• The role of folic acid and Vitamin B12 in genomic stability of human cells (4)
• Disorders of cobalamin (Vitamin B12) metabolism: Emerging concepts in pathophysiology, diagnosis and treatment (5)
• Vitamin B12 deficiency—need for a new guideline (6)
• Vitamin B12 Stalls the 80 S Ribosomal Complex on the Hepatitis C Internal Ribosome Entry Site (7)
• Folic Acid and Vitamin B12 Supplementation Improves Coronary Flow Reserve in Elderly Subjects with Vitamin B12 Deficiency (8)
• Folate (vitamin B9) and vitamin B12 and their function in the maintenance of nuclear and mitochondrial genome integrity (9)
(1) International Journal of Geriatric Psychiatry Volume 27, Issue 6, pages 592–600, June 2012
(2) Homocysteine-Lowering by B Vitamins Slows the Rate of Accelerated Brain Atrophy in Mild Cognitive Impairment: A Randomized Controlled Trial
(3) Journal of Neuroimmunology Volume 40, Issues 2–3, October 1992, Pages 225–230
(4) Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Volume 475, Issues 1–2, 18 April 2001, Pages 57–67
(5) Blood Reviews Volume 21, Issue 3, May 2007, Pages 113–130
(6) Nutrition Volume 17, Issues 11–12, November 2001, Pages 917–920
(7) Journal of Molecular Biology Volume 319, Issue 1, 24 May 2002, Pages 1–8
(8) Archives of Medical Research Volume 41, Issue 5, July 2010, Pages 369–372
(9) Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Volume 733, Issues 1–2, 1 May 2012, Pages 21–33
Vitamin B12 Fertility Benefits
Fertility Research for Vitamin B12
Infertile males have been found to have lower levels of vitamin B-12 (Andrologia). It is used to help in the maintenance of healthy nerve cells and even red blood cells. It is necessary in creating DNA. One study shows that B-12 concentration, found in seminal plasma, has a direct coorelation to sperm concentration and could possibly play a role in spermatogenesis (J Androl).
A study acknowledged in the book, Could it Be Vitamin B12? An Epidemic of Misdiagnoses by Sally Pacholok and Jeffrey Stuart, observes 36 women who had recurrent miscarriages in contrast to 40 women who had given birth to full term babies and discovered that 31% of the women which had recurrent miscarriages, showed abnormally low levels of vitamin B12, B6 and folic acid (Pacholok).
Studies conducted on the usefulness of long-term, high-doses of vitamins, particularly “Zinc, B Vitamins (B6, B12 and folic acid), Vitamin C, and Antioxidants” for treatment of oligozoospermia, found that they “are critical nutrients in the male reproductive system for proper hormone metabolism, sperm formation and motility” (Moriyama).
Homocysteine and Infertility
Adequate levels of vitamin B6, along with vitamin B12 and folate, keep levels of homocysteine low. Homocysteine is an amino acid that has been linked to heart disease when present in high levels. A Dutch study that appeared in the July 2006 issue of “Human Reproduction” looked at the effects of homocysteine and other chemicals on fertility in couples undergoing assisted reproductive technology. Researchers observed that elevated levels of homocysteine in sperm was associated with poorer-quality embryos, which they theorize may lower chances for successful conception.
Thinking of using vitamin B12 for fertility?
From animal studies, it is known that vitamin B levels can affect fertility rate and the quality of the egg.
Find out what researchers have discovered about the effects of low vitamin B12 on fertility in humans…
Research studies on using Vitamin B12 for fertility improvements
B-vitamin and homocysteine status determines ovarian response to gonadotropin treatment in sheep. Kanakkaparambil R, Singh R, Li D, Webb R, Sinclair KD. Biol Reprod. 2009 Apr;80(4):743-52.
This study showed that depriving vitamin B12 from the sheep seems to affect how the eggs response to the follicle stimulating hormone. (Follicle stimulating hormone, or FSH, stimulates egg production.)
But how common is vitamin B12 deficiency in humans and is there any link to infertility? The second study answers this all important question.
Prevalence of low serum cobalamin in infertile couples. Pront R, Margalioth EJ, Green R, et al. Andrologia. 2009 Feb;41(1):46-50.
One hundred and seventy one couples who experienced difficulties in getting pregnant were invited to participate in this study. Their cobalamin (vitamin B12) levels were measured.
Here is what they found out:
• In 74 couples (43%), one couple had B12 deficiency and in 13 couples, both partners experienced B12 deficiency.
• Moreover, in 39% of men who had poor sperm quality, they had a deficiency in vitamin B12. This study supports the theory that low B12 levels is linked to infertility, although it doesn’t say if taking B12 supplement would help improve fertility rates. Nevertheless, the researchers recommend supplementation for both male and female trying to conceive a child. This will ensure that both partners are not deficient in this essential vitamin.
Homocysteine concentrations in follicular fluid are associated with poor oocyte and embryo qualities in polycystic ovary syndrome patients undergoing assisted reproduction. Berker B, Kaya C, Aytac R, Satiroglu H. Hum Reprod. 2009 Sep;24(9):2293-302.
Females suffering from PCOS often have poor quality eggs and a low fertility rate. Research studies have shown a link between high homocysteine levels and poor egg quality in animal studies.
Note: Homocysteine is an amino acid and its level can be increased with deficiencies in folic acid, vitamin B6 (pyridoxine) and vitamin B12 (cobalamin).
In the 52 women with PCOS undergoing IVF, the researchers looked at the quality of the eggs and the homocysteine and vitamin B12 levels.
They found that higher homocysteine levels were related to low vitamin B12 levels and lower fertilization rates. Although it is not possible to conclude with certainty if taking vitamin B12 would improve the quality of the egg, it is easy enough to avoid deficiency by taking a vitamin B12 supplement.
Andrologia 2009 Feb;41(1):46-50.
J Androl 2007 Jul-Aug;28(4):521-7.
Moriyama, H., K. Nakamura, N. Sanda, E. Fujiwara, S. Seko, A. Yamazaki, M. Mizutani, K. Sagami, and T. Kitano. “Studies on the Usefulness of a Long-term, High-dose Treatment of Methylcobalamin in Patients with Oligozoospermia.” Hinyokika Kiya 33.1 (1987): 151-6. Print.
Pacholok, Sally M., and Jeffrey J. Stuart. Could It Be B12?: an Epidemic of Misdiagnoses. Sanger, CA: Quill Driver /Word Dancer, 2005. Print.
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
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